Vahid Gazestani

My research focuses on inference and analysis of biological networks, particularly gene regulatory circuits and their impacts on cellular phenotypes. In my PhD studies at McGill University, I designed large scale transcriptomics and proteomics experiments to systematically reconstruct regulatory and protein interaction networks of Trypanosoma brucei, an important human parasite. I did my postdoctoral studies at UC San Diego where I investigated the underpinning mechanisms of autism spectrum disorder (ASD). Through a series of integrative studies, I found highly heterogenous autism risk genes converge on a set of common “core” molecular processes affecting prenatal brain development and postnatal clinical phenotypes. As a computational staff scientist in the Stevens and Macosko labs, I develop integrative approaches for the analysis of single cell data to identify cell states in different biological contexts and characterize their underlying gene networks.

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